Search results for "genetics [Transcriptome]"
showing 10 items of 3033 documents
Towards human exploration of space: the THESEUS review series on cardiovascular, respiratory, and renal research priorities
2016
International audience; The THESEUS project (Towards Human Exploration of Space: aEUropean Strategy) was initiated within the seventh FrameworkProgramme by the European Commission. This project aimed toprovide a cross-cutting, life science-based roadmap for Europe’sstrategy towards human exploration of space, especially for deepspace missions and its relevance to applications on Earth. Toaddress these challenges, relevance of space research on thecardiovascular system, the lungs and kidneys, was discussed in anexpert group and its principal conclusions will be presented in thisarticle.
Molecular characterization of cyclic and obligate parthenogens in the aphid Rhopalosiphum padi (L.)
1996
Holocyclic clones of the aphid Rhopalosiphum padi (L.) reproduce by cyclic parthenogenesis, whereas anholocyclic individuals are obligate parthenogens. Mitochondrial DNA (mtDNA) and random amplified polymorphic DNA markers in R . padi as well as plasmid DNA markers of its bacterial endosymbiont, Buchnera aphidicola , were examined to determine the extent of genetic divergence between clones with these differing breeding systems. These analyses revealed that cyclically parthenogenetic lineages possessed differing mtDNA and plasmid haplotypes than most obligately asexual clones. The extent of sequence divergence between these maternally inherited molecules suggests a relatively ancient origin…
Les Gonorynchiformes fossiles : distribution et diversité.
2007
8 pages; Longtemps placés dans les clupéiformes, les Gonorynchiformes ont rejoint les Ostariophysi au sein desquels ils représentent le groupe-frère des Otophysi. La monophylie du groupe est maintenant bien établie tant par les données morphologiques que moléculaires. De nos jours, quatre familles sont représentées par sept genres (dont cinq d'eau douce) et 35 espèces (dont 28 d'eau douce). Les Gonorynchiformes fossiles sont connus depuis le Crétacé basal (soit 145-140 millions d'années) jusqu'au Miocène basal (soit 23,5-20 millions d'années), et plusieurs taxons ont de grandes extensions temporelles. Ils sont représentés par environ 18 genres et 34 espèces. Avec moins de 50 localités fossi…
Inactivation of PadR, the repressor of the phenolic acid stress response, by molecular interaction with Usp1, a universal stress protein from Lactoba…
2009
ABSTRACT The phenolic acid decarboxylase gene padA is involved in the phenolic acid stress response (PASR) in gram-positive bacteria. In Lactobacillus plantarum , the padR gene encodes the negative transcriptional regulator of padA and is cotranscribed with a downstream gene, usp1 , which encodes a putative universal stress protein (USP), Usp1, of unknown function. The usp1 gene is overexpressed during the PASR. However, the role and the mechanism of action of the USPs are unknown in gram-positive bacteria. Therefore, to gain insights into the role of USPs in the PASR; (i) a usp1 deletion mutant was constructed; (ii) the two genes padR and usp1 were coexpressed with padA under its own promo…
Managing crop nitrogen and soil dynamics
2001
Despite extensive research grain legume seed protein content and yield remains low and unstable. Grain legume performances in the cropping system are highly dependent upon N nutrition of the crop relying on root assimilation of soil N in combination with symbiotic fixation of atmospheric dinitrogen. In order to improve the competitive ability of grain legumes for growth resources an enlargement of the crop surface area production in combination with a judicious management of both inputs and N acquisition (and allocation to the harvested organs) is needed. Competitive ability implies to take into account economical constraints and the crop production effect on the environment, reducing the a…
Crustacés amphipodes de surface (Gammares d'eau douce)
2012
EA MERS CT3; National audience; L’ouvrage de Piscart & Bollache présente une clef de détermination actualisée des amphipodes de surface de la France métropolitaine. Les espèces natives et invasives sont décrites, avec une carte de la répartition de chaque espèce. L’ouvrage est agrémenté d’une partie décrivant l’écologie des amphipodes, leur comportement et leurs pathogènes les plus fréquemment rencontrés.
Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction
2015
Up to 80% of individuals with myotonic dystrophy type 1 (DM1) will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by conduction defects and supraventricular and ventricular tachycardia, and carries a high risk of sudden cardiac death. Despite its importance, very few animal model studies have focused on the heart dysfunction in DM1. Here, we describe the characterization of the heart phenotype in a Drosophila model expressing pure expanded CUG repeats under the control of the cardiomyocyte-specific driver GMH5-Gal4. Morphologically, expression of 250 CUG repeat…
Extrapolation of the Species Accumulation Curve for Incomplete Species Samplings: A New Nonparametric Approach to Estimate the Degree of Sample Compl…
2015
9 pages; International audience; Incomplete species samplings are deemed to remain the common practice in those groups of animals, such as small or micro- invertebrates, with numerous species that often are more or less difficult to detect in the field. Thus, extrapolating the Species Accumulation Curve as far as possible beyond the actual sample size may thus serve as a useful (although imperfect) surrogate to the desired, but practically inaccessible, complete samplings. In this context, several kinds of theoretical or empirical models for the Species Accumulation Curve and also a lot of estimators of the asymptotic limit of the Curve (i.e. total species richness) have been proposed. The …
Role of Chemerin in Cardiovascular Diseases.
2022
(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that disrupt cardiovascular homeostasis by activating inflammatory processes that recruit immune cells to the site of injury and reduce nitric oxide levels, resulting in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. Adipose tissue produces adipokines, such as chemerin, that may alter immune responses, lipid metabolism, vascular homeostasis, and angiogenesis. (2) Methods: We performed PubMed and MEDLINE searches for articles with English abstracts published between 1997 (when the first re…
NAD+ repletion with niacin counteracts cancer cachexia
2023
AbstractCachexia is a debilitating wasting syndrome and highly prevalent comorbidity in cancer patients. It manifests especially with energy and mitochondrial metabolism aberrations that promote tissue wasting. We recently identified nicotinamide adenine dinucleotide (NAD+) loss to associate with muscle mitochondrial dysfunction in cancer hosts. In this study we confirm that depletion of NAD+ and downregulation of Nrk2, an NAD+ biosynthetic enzyme, are common features of severe cachexia in different mouse models. Testing NAD+ repletion therapy in cachectic mice reveals that NAD+ precursor, vitamin B3 niacin, efficiently corrects tissue NAD+ levels, improves mitochondrial metabolism and amel…